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Desyrel (Trazodone)

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Desyrel is a high-quality medication which is taken in treatment of depression. This remedy is acting by increasing the amount of serotonin. It is serotonin modulator.

Other names for this medication:

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Also known as:  Trazodone.


Desyrel is a perfect remedy in struggle against depression.

This remedy is acting by increasing the amount of serotonin.

Desyrel is also known as Trazodone, Molipaxin, Deprax, Trittico, Thombran, Trialodine, Trazorel.

It is serotonin modulator.

Generic name of Desyrel is Trazodone.

Brand names of Desyrel are Desyrel, Desyrel Dividose.


Take Desyrel tablets orally with food.

Do not crush or chew it.

Take Desyrel at the same time every day with water.

Desyrel can be used by 18 year-old patients or over.

If you want to achieve most effective results do not stop taking Desyrel suddenly.


If you overdose Desyrel and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Desyrel overdosage: abnormal heartbeats, difficulty breathing, painful erection that does not go away, vomiting, feeling drowsy, convulsions.


Store at room temperature between 15 and 30 degrees C (59 to 86 degrees F) away from moisture and heat. Protect from light. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Desyrel are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Desyrel if you are allergic to its components.

Do not take Desyrel if you are pregnant, planning to become pregnant, or are breast-feeding.

Do not take it if you are under 18.

Be careful with Desyrel if you suffer from schizophrenia, other psychiatric illness, suicidal thoughts, heart attack, bipolar disorder (manic depression), drug abuse.

Avoid alcohol.

Try to avoid machine driving.

Be careful! Taking Desyrel you can become suicidal.

If you are going to have a surgery, be careful with Desyrel.

It can be dangerous to stop Desyrel taking suddenly.

desyrel dosage

Strong evidence has recently been reported that major depression is accompanied by an acute phase response (APR), characterized by elevated levels of positive acute phase proteins (APPs) and decreased levels of negative APPs. The APR is also reflected in lowered total serum protein (TSP) and specific changes in the major electrophoretically separated protein fractions. The present study examined pretreatment and posttreatment serum TSP and the concentrations and percentages of the major electrophoretically separated serum protein fractions in 37 major depressed subjects, of whom 29 had treatment-resistant depression (TRD), and in 29 normal controls. We found that TSP and the percentage and concentration of serum albumin (Alb) and gamma-globulin fraction were significantly lower in major depression and TRD than in normal controls. Serum beta-globulin concentrations were significantly lower in major depressed and TRD subjects than in normal controls. The percentages of the alpha 1- and alpha 2-globulin fractions were significantly higher in major depressed subjects than in normal controls. There were no significant effects of subchronic treatment with antidepressants on TSP, the percentage or concentration of the major electrophoretically separated protein fractions, i.e. alpha 1-, alpha 2- and beta-globulin. There was a significant increase in percentage of the gamma-globulin fraction after subchronic treatment with antidepressants. The results support the hypothesis that major depression and TRD are accompanied by a chronic APR.

desyrel dosage forms

The effects of the antidepressant drugs trazodone and imipramine on the circadian rhythm were studied by means of the sleep propensity test (SPT; sleep latency was examined by 35-minute EEG records at 09:00, 11:00, 13:00, 15:00, 17:00). The subjects were 11 healthy male volunteers (mean age, 23.6 years old). The drugs were administered 4 times a day with single blind trials using an inactive placebo as a control. The dosages of the drugs were trazodone 50-100 mg/day and imipramine 20-40 mg/day. We discussed the circadian rhythm referring to previous polysomnograhy (PSG) studies using the same drugs and dosages with most of the same subjects. As a result, the mean sleep latency of SPT was the shortest at 09:00 (p<0.1) with a placebo, at 11:00 (p<0.05) with trazodone and at 13: 00 (not significantly) with imipramine administration. These results suggested that neither drug affected sleepiness. They affected the circadian rhythm during the daytime (=the day rhythm). They delayed the day rhythm. Delay of the day rhythm was due to trazodone and have been caused by not only trazodon administration itself, but also by the increase of slow-wave sleep obtained in the previous night's PSG study. And the day-rhythm delay was due to imipramine and might have been caused by not only imipramine administration itself, but also by the decrease in the percentage of slow-wave sleep and REM sleep, and an increase in REM latency obtained in the previous night's PSG study. Therefore, we concluded that neither drug affected the tendency toward sleepiness, but did affect the day rhythm in healthy subjects.

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Sexual adverse effects are common with psychotropics. Rational polypharmacy may confound etiology. This case report describes development of ejaculatory inhibition in a male patient with co-morbid psychiatric diagnoses treated with fluoxetine, divalproex sodium, lamotrigine, trazodone, and clonazepam. Detailed psychotropic history with time-line of adverse effect onset implicated trazodone. Within 48 hours of trazodone discontinuation, ejaculatory inhibition was resolved. Clinicians should be aware that trazodone may cause ejaculatory inhibition, understand that determination of sexual adverse effects necessitates directed and periodic questioning as these symptoms may increase in severity over time, and appreciate that religious patients may find discussing this issue difficult.

desyrel overdose

We report two cases (F. 11 years, M. 7 years) with juvenile fibro-myalgic syndrome, diagnosed because of the presence of musculo-skeletal pain, tender points and associated symptoms, and after exclusion of any other known etiology. Both patients improved after treatment with antidepressant serotoninergic (amitriptyline, trazodone).

desyrel 75 mg

Thirty-seven carefully selected women aged 39 to 71 (mean 58.6 years) were randomized to receive either 200 mg of trazodone or a placebo in a similar manner. Pain and pain-related symptoms were evaluated on a visual analogue scale and other measures at 0, 2, 4, and 8 weeks.

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Patients selected for the study had an established clinical diagnosis of chronic schizophrenia with stable symptomatology, an absence of florid psychotic symptons, a stable regimen of neuroleptic medication, and an absence of depressive disorder. Active psychotic symptoms were assessed using the Brief Psychiatric Rating Scale (BPRS) score on the thinking disturbance factor. Negative symptoms were assessed using the BPRS withdrawal retardation factor as well as the affective flattening and alogia subscales from the Scale for Assessment of Negative Symptoms. Forty-nine patients were randomly assigned to either trazodone or placebo in a six-week double-blind trial.

desyrel schedule drug

Obsessive-compulsive disorder (OCD) is a severe psychiatric illness that is difficult to treat. The effects of trazodone hydrochloride treatment were studied, both with and without the addition of a monoamine oxidase inhibitor, in OCD patients. Changes in symptoms correlated with changes in local cerebral metabolic rates for glucose (LCMRGlc), as measured by positron emission tomography and the 18F-fluorodeoxyglucose method. All patients whose OCD responded favorably to drug treatment showed a relative increase in glucose metabolism in the heads of the caudate nuclei compared with the metabolic rate in the ipsilateral hemisphere as a whole (ratio LCMRGlc caudate/LCMRGlc hemisphere). Patients who did not respond to treatment did not show an increase in this ratio, and the difference between responders and nonresponders was significant (p less than 0.03). Changes in the ratio LCMRGlc caudate/LCMRGlc hemisphere correlated with changes on OCD and depression rating scales.

desyrel medication guide

The electrocardiographic and anticholinergic effects of trazodone (150 mg) and imipramine (75 mg) were investigated in 8 healthy volunteers. Both agents increased the QTc interval and decreased T wave height, but the effects occurred earlier with trazodone (from 30 min onwards) than with imipramine (150 and 180 min after dosing). Both drugs decreased heart rate, imipramine at 30 and 60 min and trazodone at 90 min. After 120 min, heart rate began to increase with imipramine an effect which was not seen with trazodone. Salivary volume was significantly decreased by imipramine at 120 and 180 min whereas trazodone did not influence salivary volume. Plasma levels of trazodone and imipramine were significantly related to the decrease in T wave amplitude. The increase in QTc interval correlated significantly with the plasma level of imipramine. These results suggest that trazodone, like the tricyclic antidepressants prolongs ventricular repolarization; but, in contrast to imipramine, it does not have anticholinergic activity.

desyrel trazodone reviews

Depression is a common and disabling condition and is especially disabling for patients who also have epilepsy. Antidepressants, particularly the tricyclic antidepressants are well known to be associated with seizure activity, but this is a very neglected area of research. Most of the data on the proconvulsive effects of antidepressants come from either work in animal models or from research into the effects of antidepressants in overdose. Both of these situations may tell us little about the behaviour of antidepressants in patients with epilepsy. The selective serotonin [5-hydroxytryptamine; 5-HT] reuptake inhibitors have a low seizure propensity, are well tolerated in overdose and have a favourable adverse effect profile, making them suitable as first line treatments for depression in patients with epilepsy. Other antidepressants, e.g. trazodone, moclobemide, mirtazepine, are also likely to have minimal proconvulsive effects, but adverse effects, interactions with other drugs, especially anticonvulsants, or the lack of clinical data may make their use less attractive. Although this review has focused on these clinically important issues it is clear that considerably more research needs to be undertaken on the seizure propensity and clinical efficacy of antidepressants in patients with epilepsy.

desyrel max dose

Trazodone has the most data suggesting efficacy. This finding is tempered by a study suggesting its association with a return to heavy drinking in some patients. Data regarding the efficacy of gabapentin are unclear at this point.

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desyrel medication guide 2016-04-23

The psychomotor, sedative and memory effects of a sedative, anticholinergic antidepressant (amitriptyline), a sedative antidepressant (trazodone) and placebo were compared in a double-blind, cross-over study with 12 healthy volunteers. Amitriptyline (37.5 mg) and trazodone (100 mg) were administered for the first 7 days of treatment and in double-dosage for the next 7 days of treatment. Subjects completed a battery of tests before and 2 h after drug administration on days 1, 8 and 14. Over the 2 weeks of treatment, there was no accumulation of effects but subjects experienced marked sedation and psychomotor impairments following a buy desyrel daily dose of both active drugs. Although both amitriptyline and trazodone produced impairments on memory tasks, the effect of amitriptyline was significantly greater and may reflect its anticholinergic action over and above global sedative effects. Tolerance to the effects of amitriptyline built up differentially over measures of sedation, psychomotor function and memory.

desyrel tablets 2017-04-01

Trazodone and dapiprazole displace ligands binding to rat brain alpha-1 adrenoceptors. The displacement of 3H-ligands to alpha-2, serotonin1 (5-HT1), dopamine, beta and opiate receptors is either absent or takes place at relatively higher concentrations. Trazodone, unlike dapiprazole, also inhibits binding to serotonin2 (5-HT2) receptors. Some pharmacological effects show a satisfactory correlation with these data. The psychopharmacological effects of trazodone and dapiprazole are similar, whereas the binding inhibition to 5-HT2 receptors is buy desyrel different, which would indicate that the psychopharmacological effects do not primarily depend on these receptors. The displacement of the binding to alpha-1 adrenoceptors by dapiprazole has a time course similar to that of its brain concentrations as well as to that of sedative and alpha-blocking effects. Dapiprazole and trazodone have antinociceptive effects and inhibit the binding to opiate receptors, although at relatively high concentrations.

desyrel cough medicine 2017-08-09

One hundred and fifty Naprosyn Mg outpatients with an MDD diagnosis, treated with antidepressants in mono-therapy, were included. Follow-up period was set at 24 months, and information have been obtained from charts, interviews with patients and their relatives, and from the Lombardy regional register. A survival analysis (Kaplan-Meier) was performed, considering recurrences, hospitalizations, or discontinuation due to side effects as 'death' events.

desyrel recommended dose 2017-05-26

Mental health is an important medical issue in perinatal care, and there is increasing evidence that insomnia during pregnancy is associated with postpartum depression (PPD). Therefore, the present study evaluated the Buy Hytrin Australia effect of insomnia treatment during the third trimester of pregnancy on PPD symptoms. Fifty-four pregnant women with insomnia were randomly assigned to trazodone, diphenhydramine, or placebo treatment. Sleep quality was measured by actigraphy at baseline, and after 2 and 6 weeks of treatment. In addition, depression was assessed 2 and 6 weeks after delivery. Trazodone and diphenhydramine improved sleep profile compared to placebo after 6 weeks of treatment. Further, depressive symptoms were reduced 2 and 6 weeks after delivery in trazodone and diphenhydramine groups compared to placebo. No differences in depressive symptoms were observed between the trazodone and diphenhydramine groups. These findings indicate that insomnia treatment with trazodone or diphenhydramine during the third trimester of pregnancy may prevent PPD.

desyrel 5 mg 2015-08-31

Trazodone has the most data suggesting efficacy. This finding is tempered Imodium Pediatric Dosage by a study suggesting its association with a return to heavy drinking in some patients. Data regarding the efficacy of gabapentin are unclear at this point.

desyrel syrup 200ml 2016-11-20

This is an edited transcription of a presentation made to a group of primary care physicians, medical students, and consultation-liaison psychiatrists. Primary care physicians frequently prescribe antidepressant medications to their patients. These medications are frequently misprescribed, often in dosages that are too low to have an optimal effect. In part this is due to generally exaggerated fears that primary care physicians have regarding these medications, especially the anticholinegic effects of recommended dosage levels and sudden cardiac death. This is rarely a problem except in overdosage or those with dangerous preexisting cardiac arrhythmias. The author reviews his thoughts about some of the more recently introduced agents, including the usual, positive, psychologic responses (placebo effects) to any new drug. The newer agents are not more Topamax 25mg Reviews efficacious than older agents but have different side-effect profiles. The common side effects, and have these may be minimized or in some cases used to the patient's advantages, are discussed for the older and newer agents.

desyrel dose 2016-07-30

Differential diagnosis includes post-stroke fatigue and the pseudo-depressive manifestations of strategic infarctions (apathy, aprosody, lack of self psychic activation syndrome, pathological crying syndrome). Functional and cognitive complications of untreated PSD can be observed. Mortality in depressed stroke patients has been estimated between 3.5 and 10 times higher than Imitrex Oral Dosage in non depressed stroke patients; suicide ideation can be observed in 11.3% of stroke patients. Clinical trials controlled with placebo have shown the efficacy of fluoxetine, nortriptiline, trazodone and citalopram in the treatment of PSD. Other therapeutic approaches include cognitive and functional rehabilitation.

desyrel review 2016-01-29

To develop a simple and sensitive Sporanox Cost Canada high-performance liquid chromatography (HPLC) assay with ultraviolet detection method of vandetanib in rat plasma.

desyrel and alcohol 2016-07-22

We present the case of a 71-year-old female suffering from bipolar affective disorder type 2 and an old lacunar brain infarct who, under the combined treatment of fluoxetine for depression and low dose trazodone for the accompanying insomnia, developed a toxic delirium. The subject presented with mental state changes (confusion and agitation), hyperreflexia, diaphoresis, nausea, vomiting, fever, and a general tonic-clonic seizure which developed soon after an increase in the trazodone dose. One year prior to the above episode, she was hospitalized for a transient episode of agitated confusion while being treated with fluvoxamine for depression, alprazolam and brotazolam for the accompanying anxiety and insomnia. Both episodes subsided spontaneously when treatment was discontinued. This case reports the possible existence of increased vulnerability to hyperserotonergic states in elderly patients suffering from concomitant psychiatric and neurological disorders.